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Unlike exogenous recombinant human growth hormone (rhGH), sermorelin stimulates physiologic GH production while preserving feedback regulation via somatostatin and IGF-1 pathways

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Common Gastrointestinal Concerns Both dual and triple agonists share a class-wide side effect profile dominated by gastrointestinal issues, primarily: Nausea Diarrhea or Constipation Vomiting These effects are dose-related and typically peak during the dose-escalation phase