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Evaluation of Solubility, Dissolution Rate, and Oral Bioavailability of β-Cyclodextrin and Hydroxypropyl β-Cyclodextrin as Inclusion Complexes of the Tyrosine Kinase Inhibitor, Alectinib

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A molecular model by Fourquet and Toledano predicted that C151 is remotely positioned from both the BTB dimerization interface and Cullin3, and also implicated the basic amino acid environment in the increased reactivity of this cysteine (Fourquet et al., 2010)