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investigated for selective fat-mobilising effects independent of GH receptor signalling Cartilage & joint research — Examined in chondrocyte models and osteoarthritis frameworks for anabolic effects on cartilage matrix synthesis Metabolic profile — Investigated for absence of the hyperglycaemic and IGF-1-elevating effects associated with full-length hGH, making it a useful tool compound for isolating GH’s metabolic effects Body composition models — Studied in rodent obesity models for changes in fat mass, lean mass, and energy expenditure Clinical research history — Progressed to early-phase human trials in Australia (2000s) for obesity and osteoarthritis indications