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Part 2 up! Does BPC-157 cause cancer? The real answer is far more nuanced than the internet makes it sound. Context, dosing, patient history, and physician oversight matter when talking about peptides.
JIMD Rep., Springer Berlin Heidelberg 36, 99–107 16 Hooijer, G
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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a γ-Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)