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By targeting NNMT—an enzyme highly expressed in adipose tissue and linked to insulin resistance—this compound allows researchers to explore how shifting cellular metabolism away from fat storage toward energy utilization can impact systemic health
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Pemetrexed was clastogenic in an in vivo micronucleus assay in mouse bone marrow but was not mutagenic in multiple in vitro tests (Ames assay, Chinese Hamster Ovary cell assay)
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