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Despite some of the limitations discussed above, the NAM toolbox for respiratory safety used in this work appeared to separate the low- and high-risk benchmark exposure scenarios for 12 out of the 14 scenarios evaluated when using the BER, suggesting that our strategy of selecting NAMs informed by AOPs associated with pulmonary toxicity, can provide relevant biological coverage
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We found that 12 of these samples belong to SNP type 2, and in these, the transcription and protein levels of OsLIKE1 were significantly upregulated under high light induction, compared to TP309 and SNP type 3 rice varieties (Fig
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