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Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L

Muscles Health

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UCHL1 promotes OCgenesis by restricting NRF2-dependent gene expression Having ruled out a general proteostatic function of UCHL1 in OCgenesis, to explore its role in differentiating OCs and understand the mechanism whereby UCHL1 supports OC differentiation, we deployed an unbiased approach through comprehensive label-free proteomics upon UCHL1 genetic and pharmacological inhibition in preOCs, achieved respectively via stable expression of anti- Uchl1 shRNAs and administration of LDN57444