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While Hck โ/โ Fgr โ/โ neutrophils can produce ROS normally in response to IgG ICs-activation, Hck โ/โ Fgr โ/โ Lyn โ/โ PMNs have defective ROS production in response to FcฮณR-mediated phagocytosis and IgG ICs (Lowell et al., 1996
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Because conjugation of the electrophilic AFB 1 -8,9-epoxide with GSH is an alternative fate to binding to nucleophilic centers in cellular macromolecules, GSTs play a critical role in the protection of tissues from the deleterious effects of bioactivated AFB 1 , and tissues vary considerably in both GST concentration and distribution of specific GST isoforms
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