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These findings suggest that Bmi1 may serve as a critical transcriptional regulator governing ABSCs self-renewal dynamics, proliferative activity, and differentiation programs during silicosis progression, providing evidence positioning Bmi1 as a promising molecular target for developing stem cell-based therapeutic interventions against silicosis ( 5.3 Induced pluripotent stem cells Induced pluripotent stem cells (iPSCs), recognized as a major breakthrough in regenerative medicine, are generated through transcription factor-mediated reprogramming of differentiated somatic cells to acquire embryonic stem cell-like pluripotency (63)
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