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Injection site management Given the elevated injection site reaction rates with cagrilintide, proactive management is especially important: Rotate injection sites systematically using a rotation schedule (abdomen, right thigh, left thigh, right arm, left arm) Allow the solution to reach room temperature before injecting Inject slowly over 5 to 10 seconds rather than quickly Apply ice before injection to reduce pain Do not massage the injection site afterward Use proper technique as outlined in our peptide injection guide Keeping a log of injection sites and reactions helps identify whether certain areas are more problematic than others