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Exposure to elevated levels of female hormones, such as during pregnancy or due to estrogen therapy and possibly oral contraceptives, further increase the risk (Pak 2016

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Similar analysis of a human embryonic stem cell line showed that 5.83% of cytosines are methylated, 82.7% of CpG dinucleotides are methylated, and 25% of all cytosine methylation occurs at non-CpG sites (10)