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A single intrastriatal injection of CDNF or MANF was found to improve locomotor behavior and rescue dopaminergic neurons in the SNpc of 6-hydroxydopamine (6-OHDA)-induced PD models [38,39]

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In addition, the clinical results of AMG510 and MTRX849 showed fewer adverse reactions and better tolerance, and the two resulted in more benefits and less toxicity when used in combination 131