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Also, Kcs1 regulates the cell cycle via production of inositol pyrophosphates, which promote cell growth by modulating the activity of some chromatin-remodeling complexes, vacuole biogenesis, and cell wall integrity
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β-Glucuronide-based ADCs derived from this framework demonstrated favorable developability profiles, including high achievable drug-to-antibody ratios, reduced aggregation driven by the hydrophilic carbohydrate motif, and improved plasma stability relative to conventional protease-cleavable dipeptide linkers
