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Importantly, the addition of an antioxidant, N -acetyl-cysteine (NAC), led to a reduction in the proportion of bigger ductal structures in Aldh1l2 KO but not WT cultures, supporting the suggestion that loss of ALDH1L2 drives ADM through increased ROS levels (Fig

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[DOI] [PubMed] [Google Scholar] 297.Campana F., Zervoudis S., Perdereau B., Gez E., Fourquet A., Badiu C., Tsakiris G., Koulaloglou S