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Additionally, in sensitive cell lines, SSI-4 decreases phosphorylation of IRS2 downstream targets, Akt and p70S6K, indicative of a functional role of this signaling pathway in SSI-4-mediated effects although more work is needed to elucidate this further (Supplementary Fig

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An increase in ROS accelerates tumor cell death, while GSH, as a key component in redox homeostasis, plays a crucial role in scavenging ROS and neutralizing exogenous metabolites in tumor cells [15]