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When stimulants, including ROS, cytokines, and VLCFA, bind to cell surface receptor toll-like receptors (TLRs), IκB is degraded, while NF-κB is activated and then migrated into nuclear, NF-κb combines with DNA responsive elements to promote transcription of genes of pro-inflammation and inflammation (92)

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Van Bever HP, Quek SC, Lim T