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However, further experimental evidence demonstrated that production of oxygen-RS actually increases during hypoxia in different animal models

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An alternate catabolic pathway includes opening of indole core of MT during oxidation catalyzed by indole amine-2,3-dioxygenase or myeloperoxidase (MPO), resulting in the formation of unstable intermediary compound N1 -acetyl- N2 -formyl-5-methoxykynuramine (AFMK), which may be transformed to more stable N1 -acetyl-5-methoxy-kynuramine (AMK) (16-19)