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Specifically, resveratrol significantly increased PKA, phosphorylated cAMP-response element binding protein (p-CREB), and BDNF expression in the hippocampus of IBS rats while decreasing PKA, p-CREB, and BDNF levels in the ileum and colon [212]

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involvement of both covalent modification of cysteinyl residue 475 and loss of heme