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Mechanistically, Hedgehog binding to the transmembrane protein patched (PTC) induces the activation of smoothened (SMO), which stimulates the expression of downstream genes such as Ccnd1 via zinc finger transcription (GLI) factors
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71 GLS1 and GLS2 are activated through phosphorylation, earning them the name phosphorylation‐activated glutaminase (PAG)
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