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Since H 2 O 2 therapy alone does not elicit EMT, but TNF-Ξ± treatment does, it is believed that NF-ΞΊB is a part of a negative feedback mechanism that controls intracellular ROS levels
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and second, it facilitates the titration procedure by - quite a paradox - artificially raising the GSSG blood levels from ~5 ΞΌM to ~100 ΞΌM
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