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Additionally, this cluster shares with the cluster MES-2 several genes related to the skeletal muscle development and structure: cells in both clusters express markers of NMJ/synapse organization (Ptprd, Tanc1/2), genes that regulate myoblasts fusion and myotube formation in differentiating myoblasts (Igfbp5, Lix1) 29,30 , lipid metabolism (Lpl) 31 (Fig

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Some hormone-targeting medications do show reduced effectiveness over time as receptors downregulate in response to sustained activation