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Exosomes have favorable characteristics for being used as a drug delivery agent, including small size, which facilitates its penetration into deep tissues (218), having a slightly negative zeta potential (219), biocompatibility, low immunogenicity, being able to cross the biological barriers such as the BBB (220) and escape immune clearance (221), low systemic toxicity, and long-term existence in the target tissue (221, 222)
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