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To determine whether the downregulation of cFLIP upon Gln deprivation is caused by an insufficient supply of nutrients for the TCA cycle, we examined the effect of supplementation with aKG, which provides substrates for the TCA cycle, on the cFLIP level

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223 Taken together, this complex network of proteins advocates for a prevalent role of calcium signaling, where levels in the cytosol and in different organelles are tightly controlled in a cell type-specific manner