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The amounts produced during roasting are variable, but generally speaking, norharman increases during roasting and harman decreases after 240°C (464°F) (Casal, 2015)

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Obviously, a growing body of preclinical evidences suggests that the induction of lipid peroxidation by inhibiting system x c - might be an effective therapeutic strategy to clear cancer cells and prevent the acquired resistance to several cancer drugs, such as lapatinib, dabrafenib and vemurafenib (Table S1) [228, 261, 262]