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However, if there is a B12 deficiency, methyl-THF will accumulate (“get trapped”) and will not reach its final destination (THF), causing what is known as the “folate trap.” This will also affect proper DNA synthesis and lead to megaloblastic anemia (not to be confused with iron deficiency anemia)

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CrossRef Current evidence and therapeutic strategies in immunotherapy for esophageal cancer: a narrative review Kabsoo Shin Journal of the Korean Medical Association.2025