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Racca and colleagues [49], after having administered ND to rats, noted an increase in adrenocorticotrophin (ACTH) (both in blood and in pituitary corticotropes), glucocorticoid receptor (GR) reduction in the hippocampus and hypothalamus cytosol, and GR translocation in the hippocampus nuclear fraction, stimulation of cortical serotonin re-uptake and activation of hippocampus cytosolic extracellular signal-regulated kinases 2 (ERK2)