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Increased levels of oxidative damage are generally interpreted to indicate increased levels of ROS
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First, when the cell’s energy charge decreases, ADP is used to regenerate ATP via the reaction catalyzed by adenylate kinase
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![Knockout Mouse Studies Show Mitochondrial CLPP Peptidase and CLPX Unfoldase to Act in Matrix Condensates Near IMM, as Fast Stress Response in Protein Assemblies for Transcript Processing, Translation, and Heme Production[v1]](https://www.preprints.org/frontend/picture/ms_xml/manuscript/545f4bd59c1aeee1d1537302f691d963/preprints-104835-g001.png)
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![Understanding the Mechanism of [4Fe-4S] Cluster Assembly on Eukaryotic Mitochondrial and Cytosolic Aconitase](https://pubs.acs.org/cms/10.1021/acs.inorgchem.9b01278/asset/images/large/ic9b01278_0008.jpeg)
