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The MTHFR gene codes for an enzyme (methylenetetrahydrofolate reductase) that converts folate (vitamin B9) into its active form

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Where the evidence actually stands To counsel a patient honestly about TB-500, a clinician needs a vocabulary for how strong the evidence is — not just whether something has been "studied." A useful way to frame it is to think of TB-500 as a "tier-four" compound : strong animal data, a mechanistically plausible rationale, and real anecdotal and case-report interest, but limited or no published human randomized controlled trials on the marketed product itself