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Future research into TLR-targeting therapies must tackle several challenges, including the control of simultaneous activation of both anti- and pro-tumor effect elicited by TLR activation, TLR tolerance, and insufficient efficacy and toxicity
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Further, the effect of quercetin was examined on the COX-2 AA pathway, but no specific data were available for its potential to inhibit the COX-1 AA pathway (Lee et al., 2017c
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