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The IGF-1 receptor (IGF-1R) is a tyrosine kinase receptor that activates multiple pathways including (but not limited to) the Phosphoinositide-3-kinase (PI3K)/Protein kinase B (PKB or AKT), Ras/Raf/Mitogen-activated protein kinase (MAPK), and Shc [11]

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Among the distinct tau transgenic mouse models, senescence was a robust and invariant response to tau accumulation that correlated with brain atrophy in mice and human PSP (35)

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