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mutations in this gene are the most common causes of hemolytic anemia worldwide, yet protect individuals from malaria Transketolase: thiamine-requiring enzyme, enzyme of the nonoxidative stage of the PPP that transfers 2-carbon units Transaldolase: thiamine-requiring enzyme, enzyme of the nonoxidative stage of the PPP that transfers 3-carbon units Oxygen burst: phagocytic cells of the immune system utilize NADPH generated via the PPP to generate superoxide radicals to kill phagocytized microorganisms