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Administration of nirmatrelvir-ritonavir has been used for patients with persistent SARS COV-2, since some studies suggest that the persistence of SARS-CoV-2 in tissues and especially in the intestinal microbiome and virome may be involved in the pathogenesis of L-C19 (250)

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Elevation in homocysteine is expected with cobalamin deficiency due to reduced methionine synthase activity even in the face of extreme cobalamin deficiency

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