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Karyopyknotic cells in the affected brain areas (0–4), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) were analyzed as follows (score 0 indicates no change): score 1: a few karyopyknotic of neuronal cells (≤20%)

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647 However, ricoliostat has a favorable safety and tolerability profile and does not exclude the possibility that longer treatment may have a therapeutic effect on DPN or other small fiber neuropathies