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Semaglutide vs Retatrutide: Mono- vs Triple-Agonist Mechanisms A mechanistic comparison of semaglutide's selective GLP-1R agonism and retatrutide's tri-agonism at GLP-1R, GIPR, and GCGR, covering receptor pharmacology, Phase 2/3 efficacy data, and regulatory status as of 2026

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