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Studji prekliniċi juru li fibroblasti kkurati juru żieda ta '2.8-darbiet u 2.3 darbiet fl-espressjoni tal-ġeni COL1A1 (katina tal-collagen 1 tat-tip I) u COL3A1 (katina tal-collagen tat-tip III 1), rispettivament, li jaqbżu l-istimulazzjoni ta' TGF waħedha (darbiet 1.5 u 1.2)
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