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To circumvent this problem, the authors designed a strategy to “disable” the CD8 + epitope contained in the B24–C36 peptide, in other words, to prevent CD8 + T cells from recognizing this epitope, while preserving the ability to induce regulatory CD4 + T cells (Figure 1 and Table 1)

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Finally, lebrikizumab-Ibkz may cause headaches in some people