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The most common side effects of NAC include: Upset stomach Nausea or throwing up Diarrhea Fatigue Eye irritation Itching or rash Skin swelling Wheezing Less commonly, NAC may cause: Low blood pressure Increased asthma symptoms Chest tightness or numbness around your mouth (if you inhale it) Headache Life-threatening allergic reaction (anaphylactic shock) Other considerations for N-acetylcysteine NAC may also: Slow blood clotting