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In addition, many tumours downregulate argininosuccinate synthase 1 (ASS1) and become dependent on exogenous arginine, while upregulating CAT family transporters and arginase (ARG1) activity to support proliferation, polyamine synthesis, angiogenesis and nitric oxide-associated adaptation 57,58

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doi: 10.1016/j.carj.2012.04.003