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Gushen Jiedu capsule(GSJD)originated from the classic Chinese kidney tonic formula “Shuilu Erxiandan” in the Song Dynasty (1170 AD), which down-regulates pro-apoptotic protein Bcl-2-associated X protein (Bax) expression and up-regulates B cell lymphoma 2 (BCL-2) expression in the kidney of DN rats to regulate the mitochondrial apoptosis pathway

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