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In the absence of mutations in DNA repair-coding genes, FA can also underly a variant of a human inherited bone marrow failure syndrome (IBMFS) caused by mutations in both ALDH2 and ADH5 10, 14
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Ebselen has a wide range of specificity for various substrates, such as hydrogen peroxide, organic hydroperoxides (R-OOH)—unstable by-products of lipid peroxidation, cholesterol hydroperoxides (CH-OOH)—products of cholesterol peroxidation, and membrane phospholipids (Sies 1993)
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