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However, if methionine residue-35 of Aβ were substituted by norleucine (TABLE 1) in which the S-atom of Met was replaced by a CH 2 -group, giving the molecule essentially the same side-chain length and dipole moment as the native peptide, no EPR spectrum was observed (109), even though any putative metal ions suggested by others would have been present

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MOTS-C is still under research, but early data suggests it is well tolerated with no serious adverse effects