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A well-characterized GPX4-independent defense mechanism is mediated by apoptosis-inducing factor (AIF) family member 2 [AIFM2, also known as ferroptosis suppressor protein 1 (FSP1)], which suppresses lipid peroxidation by reducing coenzyme Q (CoQ) to its antioxidant form, CoQH 2 , at cellular membranes [31,32]
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This internal defense mechanism operates differently from hydrogen water’s rapid, systemic free radical neutralization, offering a complementary approach to maintaining cellular health without one being inherently better than the other
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