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First, case-control cross-sectional studies, using DCE-MRI, have shown a widespread BBB disruption, characterized by an increased rate of leakage, higher leakage volumes or the presence of hotspot leakages, within both normal-appearing WM and WMHs, in patients with cSVD relative to age-matched controls (Figure 22) (517, 520–523)

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f.) on stress and anxiety in animal models