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The NIH ME/CFS Conference II: Lipkin's Possibilities, Prusty's Big Idea, Oh's Search and Ron Davis on ALWAYS Moving Forward - Health Rising

According to the Frascati criteria [Box 2], HAND is classified into three categories based on degree of impairment: asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND), and HIV-associated dementia (HAD).[] The broad outlines of the Frascati criteria are mentioned in Box 2

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Amino acids, critical activators of mTORC1, are transported into lysosomes, where they play a pivotal role in recruiting and activating mTORC1 at the lysosomal surface