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3.1.4 Suppresses the infiltration of inflammatory cells and mediators The maintenance of the intestinal epithelial barrier requires a balance of pro- and anti-inflammatory mediators in the gut (Shi et al., 2021), the expression of colonic pro-inflammatory mediators, including IL-6, IL-1β, and TNF-α were suppressed, yet the expression of IL-10 was upregulated by Aloe vera treatment, suggesting a role of this herb in regulating inflammatory cytokines