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The specific mechanism is not clear ( Figure 2 2.3 Fatty acid metabolism In recent years, researchers have paid more attention to fatty acid metabolism in tumor cells because fatty acids are not only the main components of membrane formation, but also a source of energy supply and secondary messengers of signal transduction in rapidly proliferating tumor cells ( 3 Neuroendocrine system The endocrine/neuroendocrine system includes the endocrine organs like the pineal gland, adrenal gland, pituitary gland, thyroid gland, and parathyroid gland, as well as clusters of endocrine cells such as the pancreatic islets of Langerhans, bronchial neuroepithelial bodies, scattered epithelial endocrine cells (such as gastrointestinal endocrine cells), and neurons ( via the vascular system ( Table 1 )
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To address the potential bias from sparse data (a small number of female smokers with gout), we performed a sensitivity analysis using Firthโs penalized likelihood logistic regression
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