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coli or Staphylococcus aureus (18 , 19,) that contribute to ongoing exacerbations of flares, however, these are prescribed only after stool testing, when it can be determined what species need to be targeted
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In 1999, a rare ApoE4 mutant, APOE4 -L28P Pittsburgh variant, in which the substitution from leucine to proline occurs at position 28 of APOE4 , was discovered in the heterozygous form when screening the ApoE mutants in white LOAD patients who were from Pittsburgh, Indiana, and Mayo Clinic Rochester (Kamboh et al., 1999)