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Conclusion Overcoming PDAC requires understanding its metabolic flexibility as both a cellular trait (subtype plasticity) and an ecosystem characteristic (metabolic symbiosis)

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Contrary to the previous study, another study reported that a 50 μM concentration of H 2 O 2 causes a twofold increase in cAMP production through adenylyl cyclase activation that leads to PKA-dependent protein tyrosine phosphorylation essential for capacitation [25]