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Activation of SIRT increases resistance to OS (Haigis and Sinclair, 2010) through an increase in metabolic pathways responsible for the detoxification of ROS (Salvatori et al., 2017) such as superoxide dismutase 2 (SOD2), isocitrate dehydrogenase 2 (IDH2) and CAT (Tennen and Chua, 2011)
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Probing of the dural sac should be performed intraoperatively if intraoperative findings do not match the preoperative imaging results
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