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26,64,78 Recently, more powerful human trials, such as the FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) study, a 5-year phase 2 study with over 500 patients and extending at least 2 years, found that 3 once-weekly injections of 100 µg sprifermin provided a significant improvement in tibiofemoral cartilage thickness when administered every 6 months, compared with placebo